Alumni Wall of Fame

Rinaldo A. Mezzarane, Post-Doctoral Fellow (Brazil) 2008 - 2010


Bachelor in Biology, M.Sc. and Ph.D. in Neuroscience at University of Sao Paulo.

He worked as a Post-Doctoral fellow in the Rehabilitation Neuroscience Laboratory from 2008 - 2010 under the supervision of Dr. E Paul Zehr. His main research topic was the study of spinal cord neurophysiology including neural control of locomotion and posture. Rinaldo investigated homosynaptic depression and presynaptic modulation of soleus stretch reflex in stroke survivors during locomotor activity.

Other interests: playing guitar and listening to music like rock (Pink Floyd, RUSH, Led Zeppelin…), Jazz (Weather Report, Spirogyra, TJB,…), classical guitar and, of course, Brazilian music (Paulinho Nogueira, Yamandu Costa, Marisa Monte, …). He also likes to play basketball and swimming.

Besides the study of neural interaction between arms and legs in healthy and stroke participants, his research activities also focus on neural mechanisms involved in the control of balance and on the study of bilateral reflex variability under different types of conditioning. Electrophysiological and biomechanical approaches have been used in these studies. Additional tools of biomedical signal processing, such as digital filtering and spectral analysis, are also employed in these investigations. Topics for future research include the effects of cognitive processes on spinal cord networks and simulations using mathematical models.

Rinaldo collaborated on the following projects

  • Investigation of presynaptic mechanisms involved in the modulation of stretch reflex excitability in stroke subjects.
  • Study of changes in the excitability of common interneurons interposed in cutaneous reflex pathways in response to rhythmic movement of remote limbs.
  • Characterization of differential effects from rhythmic arms movement on stretch and H-reflexes evoked in the soleus muscle.


  • Mezzarene RA, Klimstra M, Lewis A, Hundza SR, Zehr EP (2010) Interlimb coupling from the arms to legs is differentially specified for populations of motor units comprising the compound H-reflex during “reduced” human locomotion. Experimental Brain Research. DOI 10.1007/s00221-010-2467-0
  • Mezzarane RA and Kohn AF (2009) A method to estimate EMG crosstalk between two muscles based on the silent period following an H-reflex. Medical Engineering & Physics 31, 1331-1336.
  • Mezzarane RA and Kohn AF (2008) Postural control during kneeling. Experimental Brain Research 87, 395 - 405.
  • Mezzarane RA and Kohn AF (2007) Control of upright stance over inclined surfaces. Experimental Brain Research 180, 377 - 388.
  • Mezzarane RA and Kohn AF (2002) Bilateral soleus H-reflexes in humans elicited by simultaneous trains of stimuli: symmetry, variability, and covariance. Journal of Neurophysiology 87, 2074 - 2083.

Papers in preparation

  • Mezzarane RA and Zehr EP. Evidence for locomotor linkage between the arms and legs in humans: the effect of arm cycling on H-reflex variability.
  • Mezzarane RA, Nakajima T, Zehr EP. Interaction between ascending signals related to locomotor activity of the legs and isometric voluntary contraction of arm muscles: modulation of bilateral H-reflex excitability.
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